emfizz.com
emfizz.com July 22, 2017


Wonder drug may prevent brain cell death

22 April 2017, 01:29 | Todd Saunders

Wonder drug may prevent brain cell death

Professor Giovanna Mallucci

The study finds that a licensed antidepressant called trazodone and a compound in liquorice called dibenzoylmethane (DBM) are able to reduce brain cell death in mice with prion disease and with frontotemporal dementia.

Study leader Prof. Giovanna Mallucci, of the MRC's Toxicology Unit and the University of Cambridge in the United Kingdom, and colleagues believe that their findings could lead to much-needed treatments for Alzheimer's disease and other neurodegenerative diseases in as little as 2 to 3 years.

"We're very unlikely to cure them completely, but if you arrest the progression you change Alzheimer's disease into something completely different so it becomes liveable with", she added.

Looking back, in 2013 a United Kingdom medical research council team was able to stop brain cells from dying in an animal as reported by BBC. This feat was a first of its nature to be accomplished, thus making global headlines and sparking enthusiastic hopes for people suffering from degenerative illnesses such as Alzheimer's, Parkinson's, multiple sclerosis and Huntington's.

The present study was conducted in continuation to a similar study made in 2013.

The research was funded by the MRC and Professor Mallucci was also funded by a grant from Alzheimer's Society and Alzheimer's Drug Discovery Foundation.

Misfolded proteins build up in the brain in several neurodegenerative diseases and are a major factor in dementias such as Alzheimer's and Parkinson s as well as prion diseases. This is a natural defense strategy of the brain cells, in which the brain cells shut down intracellular protein production and undergo apoptosis as soon as they detect a significant quantity of intracellular misfolded proteins.

Though it is expected that trazodone will exert the same neuroprotective role on human brain cells as it did in experimental mice models, its possible effects in reversing the effects of already inflicted damage on the brain cells is not known.

Should Investors Sell on Philip Morris' Q1 Miss?
Despite promising signs about the company's long-term future, few shareholders were happy with Philip Morris' current situation. Equities research analysts forecast that Philip Morris International will post $4.87 earnings per share for the current year.


North Korea drivers scramble as gas stations limit services
The Su Pung, which also flies a North Korean flag, was shown to be at a berth at the port's Jintang coal terminal, data showed. North Korea has conducted five nuclear tests since the early 2000s, all of which have been roundly condemned by China.


United Kingdom lawmakers approve PM's call for early election
She had also backed the Remain camp in the June 23 referendum, but kept a low profile throughout a polarising campaign. She needed to win the backing of more than two thirds of parliament's 650 members in order to hold an early election.


For the new study, Prof. However, the effectiveness of Trazodone for humans with dementia has yet to be proven.

The researchers identified a number of compounds that showed promise for restoring protein production in the brain cells of neurodegenerative disease mouse models.

Prion diseases refer to a group of progressive neurodegenerative conditions, which can affect both animals as well as humans.

FTD is a type of dementia caused by the loss of brain cells in the frontal lobes of the brain. Further tests have now revealed existing drugs designed originally as anti-depressant and anti-cancer therapies that can do the same and that are potentially safe for human use.

In most of the mouse models of prion disease, both drugs prevented signs of brain cell death by recovering protein production, and in FTD mouse models, the drugs restored memory.

Fortunately, a study reveals that Trazodone may have another goal; slowing down brain shrinkage. Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice, Brain (2017).

The team notes that the side effects of both drugs were minimal.



Other News

Trending Now

Attacker kills French policeman, injures two others, IS claims responsibility
The terrorist group said it was behind the attack and named the gunman as Abu Yusuf al Beljiki, suggesting he was from Belgium. France has lived under a state of emergency declared following a terrorist attack in November 2015 that left 130 dead.

RJD scoffs at Sushil Modi's allegations against Lalu, Tej Pratap
This way, the land as well as the money generated through its inflated value remained with the family. The Katyals had already separated themselves from the firm in 2014.

Palace frowns at De Lima in TIME 100 list
Duterte and De Lima were included in the list, which also had actors, musicians, business leaders, activists and scientists. The list released on Thursday placed Duterte under the "Leaders" category, while de Lima was listed among " Icons ".

Markets Right Now: Banks lead early stock gains
Be proactive - Use the "Flag as Inappropriate" link at the upper right corner of each comment to let us know of abusive posts. As a result, the yield on the benchmark ten-year note, which moves opposite of its price, rose by 2.3 basis points to 2.202%.

Paris terror attack will affect French elections
Trump tweeted hours after a gunman shot dead a policeman and wounded two others on the world-famous Champs Elysees boulevard. The gunman, who was shot dead by police, had a long criminal record, a source close to the investigation told CNN.

Man rescued at sea denied request for sealing of warrant
A lawyer for Nathan Carman argued it could hurt his client's efforts to find a job if the document remained in the public domain. Dan Small, a lawyer for Linda Carman's sisters, said the family does not have a position on the request to seal the warrant.

Steve Hansen: Dylan Hartley would have been "an asset" to Lions
Warburton will be supported by a number of other former Lions with 2 players on their third and 14 on their second tour. New Zealand , the current world champion and top-ranked team, hasn't lost a three-test series since 1994.

Automatic Data Processing (ADP) Rating Reiterated by BMO Capital Markets
BlackRock Institutional Trust Company N.A. boosted its stake in shares of Automatic Data Processing by 1.0% in the third quarter. Mendon Capital Advisors Corp owns 600,761 shares or 0.81% of their United States portfolio. (NYSE:NLY) for 77,560 shares.

Gevo, Inc. (NASDAQ:GEVO) , Aflac Incorporated (NYSE:AFL)
The fund owned 82,349 shares of the financial services provider's stock after buying an additional 68 shares during the period. Analyst Recommendations are opinions given by analysts to their clients about whether a given stock is worth buying or not.

U.K. Elections - Impact On British Pound
All said and done, however, whatever be the outcome of the election, Brexit is a reality from which there is no going back. However, says Stephen Bush in the New Statesman , the general public "tend to resent snap elections and turnout may drop".