Where to cut your own Christmas tree in MI this year
'Trouble in Toyland' - Watchdog Group Lists Problem Toys
President Buhari mourns Former Vice President, Alex Ekwueme
Pakistan considering India's response on Jadhav
Fiji defeat New Zealand 4-2 in thrilling quarter-final
Wonder drug may prevent brain cell death
22 April 2017, 01:29 | Todd Saunders
The study finds that a licensed antidepressant called trazodone and a compound in liquorice called dibenzoylmethane (DBM) are able to reduce brain cell death in mice with prion disease and with frontotemporal dementia.
Study leader Prof. Giovanna Mallucci, of the MRC's Toxicology Unit and the University of Cambridge in the United Kingdom, and colleagues believe that their findings could lead to much-needed treatments for Alzheimer's disease and other neurodegenerative diseases in as little as 2 to 3 years.
Looking back, in 2013 a United Kingdom medical research council team was able to stop brain cells from dying in an animal as reported by BBC. This feat was a first of its nature to be accomplished, thus making global headlines and sparking enthusiastic hopes for people suffering from degenerative illnesses such as Alzheimer's, Parkinson's, multiple sclerosis and Huntington's.
The present study was conducted in continuation to a similar study made in 2013.
The research was funded by the MRC and Professor Mallucci was also funded by a grant from Alzheimer's Society and Alzheimer's Drug Discovery Foundation.
Misfolded proteins build up in the brain in several neurodegenerative diseases and are a major factor in dementias such as Alzheimer's and Parkinson s as well as prion diseases. This is a natural defense strategy of the brain cells, in which the brain cells shut down intracellular protein production and undergo apoptosis as soon as they detect a significant quantity of intracellular misfolded proteins.
Though it is expected that trazodone will exert the same neuroprotective role on human brain cells as it did in experimental mice models, its possible effects in reversing the effects of already inflicted damage on the brain cells is not known.
Pence in Indonesia With Trade on Agenda
National Security Agency's mass surveillance, published the coup article by freelance journalist Allan Nairn earlier this week. He paved the way for a bigger US military presence in the Philippines, where American bases were shuttered 25 years ago.
NYC marathon champ dies while coaching
Fleming died of an apparent heart attack at a track meet in Verona on Wednesday afternoon, the Montclair Kimberley Academy said. He had a pulse when he was taken to Mountainside Hospital, where he was pronounced dead.
For the new study, Prof. However, the effectiveness of Trazodone for humans with dementia has yet to be proven.
The researchers identified a number of compounds that showed promise for restoring protein production in the brain cells of neurodegenerative disease mouse models.
Prion diseases refer to a group of progressive neurodegenerative conditions, which can affect both animals as well as humans.
FTD is a type of dementia caused by the loss of brain cells in the frontal lobes of the brain. Further tests have now revealed existing drugs designed originally as anti-depressant and anti-cancer therapies that can do the same and that are potentially safe for human use.
In most of the mouse models of prion disease, both drugs prevented signs of brain cell death by recovering protein production, and in FTD mouse models, the drugs restored memory.
Fortunately, a study reveals that Trazodone may have another goal; slowing down brain shrinkage. Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice, Brain (2017).
The team notes that the side effects of both drugs were minimal.
Epilepsy drug linked to birth defects
The regulator itself said the figures should be "interpreted with caution", according to Sanofi's statement. Medically necessary exceptions, he added, should be rare and accompanied by "mandatory contraceptive use".
Man rescued at sea denied request for sealing of warrant
A lawyer for Nathan Carman argued it could hurt his client's efforts to find a job if the document remained in the public domain. Dan Small, a lawyer for Linda Carman's sisters, said the family does not have a position on the request to seal the warrant.
Gevo, Inc. (NASDAQ:GEVO) , Aflac Incorporated (NYSE:AFL)
The fund owned 82,349 shares of the financial services provider's stock after buying an additional 68 shares during the period. Analyst Recommendations are opinions given by analysts to their clients about whether a given stock is worth buying or not.
Three soldiers killed by Boko Haram IED in Borno
He said troops recovered AK 47 rifles, nine rounds of ammunition and 22 rounds of North Atlantic Treaty Organisation ammunition. Enenche was holding a seminar with defence correspondents and will revert back as soon as possible.
BHP Billiton Limited (NYSE:BHP) Reviewed By Analysts
BHP Billiton PLC (LON:BLT) had its stock rating reiterated as "Equal weight" in a report released by analysts at Barclays Capital. Commerzbank Aktiengesellschaft FI's holdings in BHP Billiton Limited were worth $5,664,000 at the end of the most recent quarter.
Markets Right Now: Banks lead early stock gains
Be proactive - Use the "Flag as Inappropriate" link at the upper right corner of each comment to let us know of abusive posts. As a result, the yield on the benchmark ten-year note, which moves opposite of its price, rose by 2.3 basis points to 2.202%.
Amir Muqam hails verdict of SC about Panama Papers
The PTI member mocked at members of treasury benches and claimed that they have not thoroughly read the decision. If Nawaz Sharif had any moral standing or courage, he would have had resigned by now, the PTI spokesperson said.