emfizz.com
emfizz.com May 26, 2017


Wonder drug may prevent brain cell death

22 April 2017, 01:29 | Todd Saunders

The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt Jakob disease and dementia

The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt Jakob disease and dementia

The study finds that a licensed antidepressant called trazodone and a compound in liquorice called dibenzoylmethane (DBM) are able to reduce brain cell death in mice with prion disease and with frontotemporal dementia.

Study leader Prof. Giovanna Mallucci, of the MRC's Toxicology Unit and the University of Cambridge in the United Kingdom, and colleagues believe that their findings could lead to much-needed treatments for Alzheimer's disease and other neurodegenerative diseases in as little as 2 to 3 years.

"We're very unlikely to cure them completely, but if you arrest the progression you change Alzheimer's disease into something completely different so it becomes liveable with", she added.

Looking back, in 2013 a United Kingdom medical research council team was able to stop brain cells from dying in an animal as reported by BBC. This feat was a first of its nature to be accomplished, thus making global headlines and sparking enthusiastic hopes for people suffering from degenerative illnesses such as Alzheimer's, Parkinson's, multiple sclerosis and Huntington's.

The present study was conducted in continuation to a similar study made in 2013.

The research was funded by the MRC and Professor Mallucci was also funded by a grant from Alzheimer's Society and Alzheimer's Drug Discovery Foundation.

Misfolded proteins build up in the brain in several neurodegenerative diseases and are a major factor in dementias such as Alzheimer's and Parkinson s as well as prion diseases. This is a natural defense strategy of the brain cells, in which the brain cells shut down intracellular protein production and undergo apoptosis as soon as they detect a significant quantity of intracellular misfolded proteins.

Though it is expected that trazodone will exert the same neuroprotective role on human brain cells as it did in experimental mice models, its possible effects in reversing the effects of already inflicted damage on the brain cells is not known.

Warning for pressures on Lancashire police
The people of Gwent should be proud of the Force's performance and for the good level of service it provides. Getting this right can be not just life changing but life saving".


VP Pence praises Indonesia's democratic, tolerant values
The Vicepresident defended the need of an agreement for both parts that allows USA exporters a full participation in the Indonesian market.


Part Five Of Injustice 2 Shattered Alliances Brings In Brainiac
With this success, Netherrealm aim to improve upon their already solid formula with Injustice 2 . Brainiac is coming to Injustice 2 and he's everything we want Super Villain.


For the new study, Prof. However, the effectiveness of Trazodone for humans with dementia has yet to be proven.

The researchers identified a number of compounds that showed promise for restoring protein production in the brain cells of neurodegenerative disease mouse models.

Prion diseases refer to a group of progressive neurodegenerative conditions, which can affect both animals as well as humans.

FTD is a type of dementia caused by the loss of brain cells in the frontal lobes of the brain. Further tests have now revealed existing drugs designed originally as anti-depressant and anti-cancer therapies that can do the same and that are potentially safe for human use.

In most of the mouse models of prion disease, both drugs prevented signs of brain cell death by recovering protein production, and in FTD mouse models, the drugs restored memory.

Fortunately, a study reveals that Trazodone may have another goal; slowing down brain shrinkage. Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice, Brain (2017).

The team notes that the side effects of both drugs were minimal.



Other News

Trending Now

United Kingdom lawmakers approve PM's call for early election
She had also backed the Remain camp in the June 23 referendum, but kept a low profile throughout a polarising campaign. She needed to win the backing of more than two thirds of parliament's 650 members in order to hold an early election.

Service charge in hotels, restaurants not mandatory
The state governments were instructed to ensure restaurant owners inform their customers about service charge not being mandatory. A new consumer protection bill is in the works and it may resolve the issue of whether service charge is an unfair practice.

Baby 'bus death' couple facing years in jail
As the two parted ways Wiltshire gave Baker the thumbs up and it is this detectives believe was the signal to begin the ruse. Neither has shown any remorse for their actions and I am pleased with the convictions that have been handed down today.

Steve Hansen: Dylan Hartley would have been "an asset" to Lions
Warburton will be supported by a number of other former Lions with 2 players on their third and 14 on their second tour. New Zealand , the current world champion and top-ranked team, hasn't lost a three-test series since 1994.

Title-chasing Brighton rocked by freakish own goals
The defender clocked up his 300th appearance for the club to move into 23rd place in the club's all-time appearance makers. Stockdale will nearly certainly get the official credit/blame for an own goal, but it's hard to really fault him for it.

Gevo, Inc. (NASDAQ:GEVO) , Aflac Incorporated (NYSE:AFL)
The fund owned 82,349 shares of the financial services provider's stock after buying an additional 68 shares during the period. Analyst Recommendations are opinions given by analysts to their clients about whether a given stock is worth buying or not.

General election 2017: MPs back plans for 8 June poll
Before holding the election, May must first win the support of two-thirds of the parliament in a vote on Wednesday (April 19). She told MPs: "There are three things a country needs, a strong economy, strong defence and strong, stable leadership".

BHP Billiton Limited (NYSE:BHP) Reviewed By Analysts
BHP Billiton PLC (LON:BLT) had its stock rating reiterated as "Equal weight" in a report released by analysts at Barclays Capital. Commerzbank Aktiengesellschaft FI's holdings in BHP Billiton Limited were worth $5,664,000 at the end of the most recent quarter.

Over 10000 units impacted by BS-III ban: Ashok Leyland
It was not fun, but pain. "We have recently won the tenders for the supply of mine-protected vehicles and bullet-proof vehicles". The plants would be set up either as joint ventures or wholly-owned subsidiaries.

Euro steady below 3-week high, focus on French election
A new survey published Wednesday showed Macron leading on 23 percent to Le Pen's 22.5 percent - both of them down slightly. Its counterpart for volatility in Europe and Asia.VXEFA is trading near its highest since the election of U.S.