North Korea: "Mental gangster Trump is playing with fire"
Trump and Kim are like 'children in a kindergarten': Russian Federation
Tax Cuts Are Tax Reform
Kim Jong Un slams 'dotard' Donald Trump
US B1-B Bombers Fly Mission off of North Korean Coast
Epilepsy drug linked to birth defects
22 April 2017, 01:24 | Terri Saunders
Civil war flick set in Trump's US set for Cannes film festival
The types of birth defects attributed to the drug included spina bifida - a condition in which the spinal cord does not form properly, and can protrude through the skin - as well as defects of the heart and genital organs.
Valproate, which has been manufactured in France by Sanofi under the brand Depakine for epilepsy and Depakote and Depamide for bipolar disorders, is also believed to cause slow neurological development, ANSM said on Thursday.
But the drug can still be prescribed to pregnant women when all other forms of treatment for epilepsy fail.
The regulator itself said the figures should be "interpreted with caution", according to Sanofi's statement.
Valproate was approved as an anti-epileptic drug in France in 1967 and has become one of the most widely prescribed treatments worldwide given its effectiveness on adult patients.
The medication is responsible for "severe malformations" in 2,150 to 4,100 children in France, according to a preliminary study by French health authorities.
The drug is widely prescribed in the United Kingdom but doctors avoid giving it to pregnant women or anyone who may want children in future.
Sodium valproate is also prescribed under different brand names for people suffering from bipolar disorder.
A drug created to treat epilepsy and bipolar disorder may be responsible for 4,100 severe birth defects in babies, French health authorities have said. By the early 1980s, there were fears that the drug might be a factor in birth defects, including spina bifida, but prescription rules were only finally tightened in 2014.
BHP Billiton Limited (NYSE:BHP) Reviewed By Analysts
BHP Billiton PLC (LON:BLT) had its stock rating reiterated as "Equal weight" in a report released by analysts at Barclays Capital. Commerzbank Aktiengesellschaft FI's holdings in BHP Billiton Limited were worth $5,664,000 at the end of the most recent quarter.
Should Investors Sell on Philip Morris' Q1 Miss?
Despite promising signs about the company's long-term future, few shareholders were happy with Philip Morris' current situation. Equities research analysts forecast that Philip Morris International will post $4.87 earnings per share for the current year.
Mahmoud Zureik, ANSM's scientific director and co-author of the report, said in an interview with AFP news agency that the figure of "severe malformations" is notably high.
Women who took the same medication for bipolar disorder were twice as likely, the report said. Families of children with birth defects want to know why it took so long for this country's authorities to identify the serious risks associated with taking the drug during pregnancy.
Medsafe also includes warnings in its information for Epilim, but the current information sheet stops short of telling pregnant women not to take the drug.
"Like most medicines of this kind, Epilim may affect your developing baby if taken in the first trimester of pregnancy, as it is suspected of causing an increased risk of malformations in the exposed foetus".
A group of French families of children with birth defects, whose mothers took valproate while pregnant, have sued Sanofi, claiming it did not adequately warn about the risks.
"The number of victims is potentially huge", APESAC president Marine Martin told AFP.
Ms Martin says two of her children, a girl and a boy, suffered physical defects brought on by valproate.
Medically necessary exceptions, he added, should be rare and accompanied by "mandatory contraceptive use".
Conte: Chelsea now have 50-50 shot at title
Marcus Rashford and Ander Herrera's goals were scored with United's first shots on target against the Blues. We need to realise it's not over, we need to realise there are points to play for, and we have to dig in.
SB 808 would rein in charter schools
On Thursday, they made a decision to table the vote. "It has been on a downward trend.since the first year", he said. The School Board approved the $42,840,628 plan, up 2.72 percent over that of the current year, at a special meeting.
Priyanka spends time with Robert De Niro, Whoopi Goldberg
Priyanka has made a name for herself in Hollywood, as she gained fame for her tv show Quantico where she plays the lead. Priyanka spoke about Baywatch on a call from a leading news daily and revealed about her appearance in India.
Euro steady below 3-week high, focus on French election
A new survey published Wednesday showed Macron leading on 23 percent to Le Pen's 22.5 percent - both of them down slightly. Its counterpart for volatility in Europe and Asia.VXEFA is trading near its highest since the election of U.S.
Bill O'Reilly Leaves Fox News, Tucker Carlson Takes His Slot
Off-camera unseen forces raged against him, culminating in Fox News Channel's admission today that O'Reilly is getting the boot. The move came after reports of sexual harassment, which began earlier this month with a New York Times story .
North Korea promises 'super-mighty' pre-emptive strike
Next week, US Secretary of State Rex Tillerson will chair a minister-level meeting on the North Korean issue at the UN. North Korea has a long history of portraying mock violence against the United States in propaganda videos.
Amir Muqam hails verdict of SC about Panama Papers
The PTI member mocked at members of treasury benches and claimed that they have not thoroughly read the decision. If Nawaz Sharif had any moral standing or courage, he would have had resigned by now, the PTI spokesperson said.